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   A method by which subjects are selected so that two subjects with similar characteristics (for example, weight, smoking habits) are assigned to a set, but one receives Treatment A and the other receives Treatment B.


A strong and long-lasting closeness between two human beings or other creatures, such as exists between parent and child or two lovers.

The proclivity or tendency to form pairbonds; one of the five universal exigencies of being human.


A surgical procedure to remove part of the chest or abdomen lining (pleura) and some of the tissue around it.

A treatment administered through a thorascopy or existing chest tube.

Surgical procedure to remove the entire lung.

A specialist physician expert in the treatment of lung disease.

P value (statistics)
The lowest level of significance at which a given null hypothesis can be rejected; that is, the necessary criterion for determining that the result probably did not happen by chance. See statistical significance.


Patient file
Contains demographic, medical, and treatment information about a patient or subject. It may be paper-based or a mixture of computer and paper records.

Per protocol set
(valid cases, efficacy sample, evaluable subjects sample) the set of data generated by the subset of subjects who complied with the protocol sufficiently to ensure that these data would be likely to exhibit the effects of treatment, according to the underlying scientific model. Compliance covers such considerations as exposure to treatment, availability of measurements and absence of major protocol violations. See also full analysis set.

Period effect
Designated period during the course of a trial in which subjects are observed and no treatment is administered.

The branch of pharmacology that studies reactions between drugs and living structures, including the processes of bodily responses to pharmacological, biochemical, physiological, and therapeutic effects.

Branch of economics that applies cost-benefit, cost-effectiveness, cost-minimisation, and cost-utility analyses to compare the economics of different pharmaceutical products or to compare drug therapy to other treatments. Sometimes referred to as outcomes research.

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