Macrovascular Disease
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  Macrovascular Disease

Macrovascular Disease

   A disease of the large blood vessels that sometimes occurs when a person has had diabetes for a long time. Fat and blood clots build up in the large blood vessels and stick to the vessel walls. Three kinds of macrovascular disease are coronary disease, cerebrovascular disease, and peripheral vascular disease.


Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the rubella (German measles) virus.

The life-maintaining fluid which is made up of plasma, red blood cells (erythrocytes), white blood cells (leukocytes), and platelets; blood circulates through the body's heart, arteries, veins, and capillaries; it carries away waste matter and carbon dioxide, and brings nourishment, electrolytes, hormones, vitamins, antibodies, heat, and oxygen to the tissues.

A condition in which blood glucose is not well controlled. Type I diabetics make no insulin, whereas type 2 diabetics are characterized by the overproduction of insulin, but the inability of the target cells to respond to the insulin.

Pertaining to blood vessels in the brain.

At or near the surface of the body. Located away from the center structure.

Pertaining to blood vessels.


Macrobid is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): nitrofurantoin; nitrofurantoin, macrocrystalline.

Macrodantin is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): nitrofurantoin, macrocrystalline.

A group of drugs (typically antibiotics) whose activity stems from the presence of a macrolide ring, a large lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, are attached. The lactone ring can be either 14, 15 or 16-membered. Macrolides belong to the polyketide class of natural products.

Any food that contains calories and, therefore, can generate hormonal responses. Protein, carbohydrate, and fat are macronutrients.

A large phagocytic cell of the mononuclear series found within tissues. Properties include phagocytosis, and antigen presentation to T cells.

Macrophage-activating factor (MAF)
Actually several lymphokines, including interferon, released by activated T cells, which together induce activation of macrophages, making them more efficient in phagocytosis and cytotoxicity.

The visual perception that objects are larger than they actually are.

Abnormally large; in diabetes, refers to abnormally large babies that may be born to women with diabetes.

Macrotec is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): technetium tc-99m albumin aggregated kit.


Multicentre trial
A clinical trial conducted according to a single protocol but at more than one site, and therefore, carried out by more than one investigator.

Master of Fine Arts.

Mono-diet (monophagic diet)
Any regimen characterized by|(a) restriction of food intake to one specific kind of food, or (b) restriction of each meal to one specific kind of food (e.g., porridge alone for breakfast, fruits alone for lunch, and meat alone for dinner).

Master of Social Work.

Abnormally large; in diabetes, refers to abnormally large babies that may be born to women with diabetes.

Macrovascular Disease

Macular Edema
A swelling (edema) in the macula, an area near the center of the retina of the eye that is responsible for fine or reading vision. Macular edema is a common complication associated with diabetic retinopathy.|See also: Diabetic retinopathy; retina.

Maturity-Onset Diabetes
Former term for Type 2 (noninsulin-dependent) diabetes.|See: Type 2 Diabetes.

Mauriac Syndrome
A condition that occurs as the result of chronic poor control of diabetes. It leads to an enlarged liver due to excessive glycogen deposition, short stature and delayed puberty. There is usually a history of repeated hospitalizations for ketoacidosis and hemoglobin A1c tests can be as high as twice the upper level of normal. Kidney function is usually not affected although it may be an additional complication of poor control. Eating disorders are sometimes an accompaniment.

Multiple daily injections (of insulin). One of several terms that are used to describe insulin programs that are designed to obtain tight control of blood sugar by giving several shots every day.

Meal Plan
A guide for controlling the amount of calories, carbohydrates, proteins, and fats a person eats. People with diabetes can use such plans as the Exchange Lists or the Point System to help them plan their meals so that they can keep their diabetes under control.|See also: Exchange lists; point system.

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