Fragmentation
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  Fragmentation



Fragmentation

    Separation into different parts, or preventing their integration, or detaching one or more parts from the rest. A fear of fragmentation of the personality, also known as disintegration anxiety, is often observed in patients whenever they are exposed to repetitions of earlier experiences that interfered with development of the self. This fear may be expressed as feelings of falling apart, as a loss of identity, or as a fear of impending loss of one's vitality and of psychological depletion.

RELATED TERMS
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Integration
The useful organization and incorporation of both new and old data, experience, and emotional capacities into the personality. Also refers to the organization and amalgamation of functions at various levels of psychosexual development.

Fear
The affective response to an actual current external danger which subsides with the elimination of the threatening condition.

Fragmentation
Separation into different parts, or preventing their integration, or detaching one or more parts from the rest. A fear of fragmentation of the personality, also known as disintegration anxiety, is often observed in patients whenever they are exposed to repetitions of earlier experiences that interfered with development of the self. This fear may be expressed as feelings of falling apart, as a loss of identity, or as a fear of impending loss of one's vitality and of psychological depletion.

Personality
The uniqueness that characterizes an individual as a person as compared with, and in response to others, with respect to consistency or inconsistency of behavior and life-style.

Anxiety
A psychological and/or biological response to stress. Feelings of anxiety involve discomforting apprehension or concern, which may include symptoms such as cognitive difficulties, hypersensitivity, dizziness, muscular weakness, breathing difficulties, irregular heart beat, sweating, and sensations of fear. Typically, anxiety is a natural and healthy response to life experiences. However, exaggerated or chronic anxiety often indicates an anxiety disorder. Anxiety can be produced by external stress (exogenous anxiety) or internal stress (endogenous anxiety).

Development
The process of growth and differentiation.

Feelings
Those affective states which can be experienced and have arousing and motivational properties.

Psychological
Pertaining to mental life as manifested through language and behavior.



SIMILAR TERMS
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Fragile site
A term devised in 1969 by Frederick Hecht to denote a heritable point on a chromosome where gaps and breaks tend to occur.

Fragile Site, Chromosome
Susceptibility of chromosomes to breakage and translocation or other aberrations. Chromosome fragile sites are regions that show up in karyotypes as a gap (uncondensed stretch) on the chromatid arm. They are associated with chromosome break sites and other aberrations. A fragile site on the X chromosome is associated with FRAGILE X SYNDROME. Fragile sites are designated by the letters ""FRA"" followed by the designation for the specific chromosome and a letter which refers to the different fragile sites on a chromosome (e.g. FRAXA).

Fragile Sites, Chromosome
Susceptibility of chromosomes to breakage and translocation or other aberrations. Chromosome fragile sites are regions that show up in karyotypes as a gap (uncondensed stretch) on the chromatid arm. They are associated with chromosome break sites and other aberrations. A fragile site on the X chromosome is associated with FRAGILE X SYNDROME. Fragile sites are designated by the letters ""FRA"" followed by the designation for the specific chromosome and a letter which refers to the different fragile sites on a chromosome (e.g. FRAXA).

Fragile X chromosome
An X chromosome with a heritable fragile site associated with a frequent form of mental retardation -- the fragile X syndrome.

Fragile X Syndrome
Fragile X Syndrome is the most common inherited cause of mental impairment, and the most common known cause of autism. Fragile X syndrome is a genetic disorder caused by a mutation of the FMR1 gene on the X chromosome, a mutation found in 1 out of every 2000 males and 1 out of every 4000 females. Typically the FMR1 gene contains between 6 and 53 repeats of the CGG codon. In people with the disorder, the FMR1 allele has over 230 repeats.

Fragile X syndrome
One of the most common causes of inherited mental retardation and neuropsychiatric disease in human beings, affects as many as one in 2000 males and one in 4000 females. The syndrome is also known as FRAXA (the fragile X chromosome itself) and as the Martin-Bell syndrome. However, the preferred name is fragile X syndrome.

Fragile X Syndromes
A condition characterized genotypically by mutation of the distal end of the long arm of the X chromosome (at gene loci FRAXA or FRAXE) and phenotypically by cognitive impairment, hyperactivity, SEIZURES, language delay, and enlargement of the ears, head, and testes. MENTAL RETARDATION occurs in nearly all males and roughly 50% of females with the full mutation of FRAXA. (From Menkes, Textbook of Child Neurology, 5th ed, p226)

Fragilitas Ossium
Autosomal dominant COLLAGEN DISEASES resulting from defective biosynthesis of COLLAGEN TYPE I and characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. There are four major types, I-IV.

Fragilities, Chromosome
Susceptibility of chromosomes to breakage and translocation or other aberrations. Chromosome fragile sites are regions that show up in karyotypes as a gap (uncondensed stretch) on the chromatid arm. They are associated with chromosome break sites and other aberrations. A fragile site on the X chromosome is associated with FRAGILE X SYNDROME. Fragile sites are designated by the letters ""FRA"" followed by the designation for the specific chromosome and a letter which refers to the different fragile sites on a chromosome (e.g. FRAXA).

Fragility, Capillary
The lack of resistance, or susceptibility, of capillaries to damage or disruption under conditions of increased stress.

Fragility, Chromosome
Susceptibility of chromosomes to breakage and translocation or other aberrations. Chromosome fragile sites are regions that show up in karyotypes as a gap (uncondensed stretch) on the chromatid arm. They are associated with chromosome break sites and other aberrations. A fragile site on the X chromosome is associated with FRAGILE X SYNDROME. Fragile sites are designated by the letters ""FRA"" followed by the designation for the specific chromosome and a letter which refers to the different fragile sites on a chromosome (e.g. FRAXA).

Fragility, Osmotic
Red blood cell sensitivity to change in osmotic pressure. When exposed to a hypotonic concentration of sodium in a solution, red cells take in more water, swell until the capacity of the cell membrane is exceeded, and burst.

Fragility, Saline
Red blood cell sensitivity to change in osmotic pressure. When exposed to a hypotonic concentration of sodium in a solution, red cells take in more water, swell until the capacity of the cell membrane is exceeded, and burst.

Fragment C, Lipotropin
A peptide consisting of amino acid sequence 61-91 of the endogenous pituitary hormone BETA-LIPOTROPIN. The first four amino acids show a common tetrapeptide sequence with METHIONINE- and LEUCINE ENKEPHALIN. The compound shows opiate-like activity. Injection of beta-endorphin induces a profound analgesia of the whole body for several hours. This action is reversed after administration of naloxone.

Fragment, beta-Lipotropin C
A peptide consisting of amino acid sequence 61-91 of the endogenous pituitary hormone BETA-LIPOTROPIN. The first four amino acids show a common tetrapeptide sequence with METHIONINE- and LEUCINE ENKEPHALIN. The compound shows opiate-like activity. Injection of beta-endorphin induces a profound analgesia of the whole body for several hours. This action is reversed after administration of naloxone.

Fragment, Lipotropin C
A peptide consisting of amino acid sequence 61-91 of the endogenous pituitary hormone BETA-LIPOTROPIN. The first four amino acids show a common tetrapeptide sequence with METHIONINE- and LEUCINE ENKEPHALIN. The compound shows opiate-like activity. Injection of beta-endorphin induces a profound analgesia of the whole body for several hours. This action is reversed after administration of naloxone.

Fragmentation, DNA
Endonucleolytic cleavage of genomic DNA into oligonucleosomal fragments at internucleosomal sites. DNA fragmentation along with chromatin condensation are considered the hallmarks of APOPTOSIS.

Fragmentation, Internucleosomal DNA
Endonucleolytic cleavage of genomic DNA into oligonucleosomal fragments at internucleosomal sites. DNA fragmentation along with chromatin condensation are considered the hallmarks of APOPTOSIS.

Fragmentation, Sleep
The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.

Fragmentations, Sleep
The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.

Fragmentographies, Mass
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.

Fragmentography, Mass
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.

Fragments, Fab
Antigen-binding fragments composed of one entire light chain and about half of one of the heavy chains, linked to each other by disulfide bonds. Fab contains the antigen binding site which is part of the variable region of the immunoglobulin molecule.

Fragments, Fc
Crystallizable fragments composed of the carboxy-terminal halves of both heavy chains linked to each other by disulfide bonds. Fc fragments are responsible for the effector functions of antibodies (complement fixation, binding to cell membranes, and placental transport).

Fragments, Hageman-Factor
Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.

Fragments, Peptide
Partial proteins formed by partial hydrolysis of complete proteins.

Fragmin
Fragmin is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): dalteparin sodium.



PREVIOUS AND NEXT TERMS
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Flight of ideas
A nearly continuous flow of accelerated speech with abrupt changes from topic to topic that are usually based on understandable associations, distracting stimuli, or plays on words. When severe, speech may be disorganized and incoherent.

Flooding
Implosion. A behavior therapy procedure for phobias and other problems involving maladaptive anxiety, in which anxiety producers are presented in intense forms, either in imagination or in real life. The presentations, which act as desensitizers, are continued until the stimuli no longer produce disabling anxiety.


A shared psychotic disorder between 2 people, usually people who are mutually dependent upon each other.

Formal thought disorder
An inexact term referring to a disturbance in the form of thinking rather than to abnormality of content. See blocking; loosening of associations; poverty of speech.

Formication
The tactile hallucination or illusion that insects are crawling on the body or under the skin.

Fragmentation

Free association
In psychoanalytic therapy, spontaneous, uncensored verbalization by the patient of whatever comes to mind.

Fusion
The union and integration of the instincts and drives so that they complement each other and help the organism to deal effectively with both internal needs and external demands.

First responder
The first level of EMS certification. They are normally the first to arrive on scene, and activate the appropriate level of EMS response.

Faint
Temporary loss of consciousness because of an insufficient blood supply to the brain.

Fallopian tube
The tubal passageway connecting the ovary to the uterus.

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