Dysfunction
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  Dysfunction



Dysfunction

   Difficult function or abnormal function.

RELATED TERMS
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Abnormal
Not normal. Deviating from the usual structure, position, condition, or behavior. In referring to a growth, abnormal may mean that it is cancerous or premalignant (likely to become cancer).



SIMILAR TERMS
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Dysfunction Syndrome, Hypothalamic
Neoplastic, inflammatory, infectious, and other diseases of the hypothalamus. Clinical manifestations include appetite disorders; AUTONOMIC NERVOUS SYSTEM DISEASES; SLEEP DISORDERS; behavioral symptoms related to dysfunction of the LIMBIC SYSTEM; and neuroendocrine disorders.

Dysfunction Syndromes, Hypothalamic
Neoplastic, inflammatory, infectious, and other diseases of the hypothalamus. Clinical manifestations include appetite disorders; AUTONOMIC NERVOUS SYSTEM DISEASES; SLEEP DISORDERS; behavioral symptoms related to dysfunction of the LIMBIC SYSTEM; and neuroendocrine disorders.

Dysfunction, Central Auditory
Disorders of hearing or auditory perception resulting from disease of the central auditory pathways or auditory association cortical areas. These include HEARING LOSS, CENTRAL; cortical deafness; and AUDITORY PERCEPTUAL DISORDERS. Above the level of the pons, bilateral lesions are usually required to produce auditory dysfunction.

Dysfunction, Cerebellar
Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.

Dysfunction, Communicative
Disorders of verbal and nonverbal communication caused by receptive or expressive LANGUAGE DISORDERS, cognitive dysfunction (e.g., MENTAL RETARDATION), psychiatric conditions, and HEARING DISORDERS.

Dysfunction, erectile
A consistent inability to sustain an erection sufficient for sexual intercourse. Also commonly known as "impotence." Medically, the term "erectile dysfunction" is used to differentiate impotence from other problems that interfere with sexual intercourse (such as lack of sexual desire and problems with ejaculation and orgasm). Impotence usually has a physical cause, such as disease, injury, drug side-effects, or a disorder that impairs blood flow in the penis. Impotence is treatable in all age groups.

Dysfunction, Erectile
The inability to perform sexual intercourse.

Dysfunction, General Peroxisomal
A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; infantile Refsum disease; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders.

Dysfunction, Left Ventricular
A condition in which the left ventricle of the heart exhibits a decreased functionality. This decreased function could lead to congestive heart failure or myocardial infarction, among other cardiovascular diseases. Diagnostic measurements that indicate this condition include a diminished ejection fraction and a depressed level of motility of the left ventricular wall.

Dysfunction, Minimal Brain
A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-IV)

Dysfunction, Multiple Peroxisomal
A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; infantile Refsum disease; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders.

Dysfunction, Neurologic
Clinical signs and symptoms caused by nervous system injury or dysfunction.

Dysfunction, Phagocyte Bactericidal
Disorders in which phagocytic cells cannot kill ingested bacteria; characterized by frequent recurring infection with formulation of granulomas.

Dysfunction, Psychological Sexual
Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. (APA, DSM-IV, 1994)

Dysfunction, Psychosexual
Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. (APA, DSM-IV, 1994)

Dysfunction, Right Ventricular
A condition in which the right ventricle of the heart exhibits a decreased functionality. This decreased function could lead to congestive heart failure or myocardial infarction, among other cardiovascular diseases. Diagnostic measurements that indicate this condition include a diminished ejection fraction and a depressed level of motility of the right ventricular wall.

Dysfunction, Single Peroxisomal
A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; infantile Refsum disease; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders.

Dysfunction, Sleep Initiation
Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.

Dysfunction, Ventricular
A condition in which the ventricles of the heart exhibit a decreased functionality.

Dysfunctional
Working improperly or abnormally.

Dysfunctions, Central Auditory
Disorders of hearing or auditory perception resulting from disease of the central auditory pathways or auditory association cortical areas. These include HEARING LOSS, CENTRAL; cortical deafness; and AUDITORY PERCEPTUAL DISORDERS. Above the level of the pons, bilateral lesions are usually required to produce auditory dysfunction.

Dysfunctions, Communicative
Disorders of verbal and nonverbal communication caused by receptive or expressive LANGUAGE DISORDERS, cognitive dysfunction (e.g., MENTAL RETARDATION), psychiatric conditions, and HEARING DISORDERS.

Dysfunctions, Erectile
The inability to perform sexual intercourse.

Dysfunctions, General Peroxisomal
A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; infantile Refsum disease; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders.

Dysfunctions, Left Ventricular
A condition in which the left ventricle of the heart exhibits a decreased functionality. This decreased function could lead to congestive heart failure or myocardial infarction, among other cardiovascular diseases. Diagnostic measurements that indicate this condition include a diminished ejection fraction and a depressed level of motility of the left ventricular wall.

Dysfunctions, Multiple Peroxisomal
A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; infantile Refsum disease; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders.

Dysfunctions, Neurologic
Clinical signs and symptoms caused by nervous system injury or dysfunction.

Dysfunctions, Phagocyte Bactericidal
Disorders in which phagocytic cells cannot kill ingested bacteria; characterized by frequent recurring infection with formulation of granulomas.

Dysfunctions, Psychological Sexual
Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. (APA, DSM-IV, 1994)

Dysfunctions, Psychosexual
Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. (APA, DSM-IV, 1994)

Dysfunctions, Right Ventricular
A condition in which the right ventricle of the heart exhibits a decreased functionality. This decreased function could lead to congestive heart failure or myocardial infarction, among other cardiovascular diseases. Diagnostic measurements that indicate this condition include a diminished ejection fraction and a depressed level of motility of the right ventricular wall.

Dysfunctions, Single Peroxisomal
A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; infantile Refsum disease; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders.

Dysfunctions, Sleep Initiation
Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.

Dysfunctions, Ventricular
A condition in which the ventricles of the heart exhibit a decreased functionality.



PREVIOUS AND NEXT TERMS
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Dynacin
Brand name for minocycline.

Dynein
A family of microtubule motor proteins that derive energy from ATP (adenosine triphosphatase) activity. The dyneins also form arms on the outer tubules of cilia and flagella.

DYS
Symbol for familial dysautonomia or a prefix denoting an inability or lack of function, as in dyspraxia (lack of ability to adequately control muscle movements).

Dyscrasia
Any disease condition, especially in hematology, as in "blood dyscrasias."

Dysentery, amebic
Dysentery (inflammation of the intestine) with ulcers in the colon due to infection with an ameba (Entamoeba histolytica). This single-celled parasite is transmitted to humans via contaminated water and food.

Dysfunction

Dysfunction, erectile
A consistent inability to sustain an erection sufficient for sexual intercourse. Also commonly known as "impotence." Medically, the term "erectile dysfunction" is used to differentiate impotence from other problems that interfere with sexual intercourse (such as lack of sexual desire and problems with ejaculation and orgasm). Impotence usually has a physical cause, such as disease, injury, drug side-effects, or a disorder that impairs blood flow in the penis. Impotence is treatable in all age groups.

Dyshidrotic eczema
Irritation of the skin on the palms of hands and soles of the feet characterized by clear, deep blisters that itch and burn.

Dyskeratosis congenita
An inherited cause of bone-marrow failure, dyskeratosis congenita is a syndrome characterized by abnormal excess skin pigmentation, abnormal or absent nails, and mucosal leukoplakia (white premalignant areas on the lips and conjunctiva of the eyes and in the mouth, anus, and urethra).More than 80% of patients with dyskeratosis congenita develop bone-marrow failure with decreasing production of all types of blood cells (pancytopenia). Premature death is caused by the bone-marrow failure (in 20% of cases), malignant transformation of the leukoplakia (30%), or overwhelming infections (50%) associated with immune deficiency. Most cases of the disease are X-linked. They are due to mutations (changes) in a gene on the X chromosome called DKC1 which encodes a protein called dyskerin. A seemingly-normal mother carrying the DKC1 mutation has a 50:50 chance of transmitting it to a son who then will suffer from the disease. The average age at death is 24 years.

Dyslipidemia
A disorder of lipoprotein metabolism, including lipoprotein overproduction or deficiency. Dyslipidemias may be manifested by elevation of the total cholesterol, the "bad" low-density lipoprotein (LDL) cholesterol and the triglyceride concentrations, and a decrease in the "good" high-density lipoprotein (HDL) cholesterol concentration in the blood.

Dysmetabolic syndrome X
A constellation of metabolic abnormalities in serum or plasma insulin/glucose level ratios, lipids (triglycerides, LDL cholesterol subtypes and/or HDL cholesterol), uric acid levels, coagulation factor imbalances and vascular physiology. (This is the official definition by the American Association of Clinical Endocrinologists of this condition which is also known as the metabolic syndrome and syndrome X.)

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