Deoxyribonucleases
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  Deoxyribonucleases



Deoxyribonucleases

   Enzymes which catalyze the hydrolases of ester bonds within DNA. EC 3.1.-.

RELATED TERMS
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Enzymes
Proteins that act as a catalysts in mediating and speeding a specific chemical reaction.

Hydrolases
Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.

DNA
Deoxyribo-Nucleic acid. DNA molecules carry the genetic information necessary for the organization and functioning of most living cells and control the inheritance of characteristics.



SIMILAR TERMS
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Deoxyadenine Nucleotides
Adenine nucleotides which contain deoxyribose as the sugar moiety.

Deoxyadenosine
Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.

Deoxyadenosine Phosphates
Adenine nucleotides which contain deoxyribose as the sugar moiety.

Deoxyadenosines
Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.

Deoxyadrenaline
Sympathomimetic, vasoconstrictor agent.

Deoxycholate
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Deoxycholate, Glycine
A bile salt formed in the liver by conjugation of deoxycholate with glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and choleretic.

Deoxycholate, Sodium
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Deoxycholate, Taurine
A bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholagogue and choleretic, also industrially as a fat emulsifier.

Deoxycholic Acid
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Deoxycholic Acid, 12beta Isomer
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Deoxycholic Acid, 12beta-Isomer
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Deoxycholic Acid, 3beta Isomer
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Deoxycholic Acid, 3beta-Isomer
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Deoxycholic Acid, 5alpha Isomer
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Deoxycholic Acid, 5alpha-Isomer
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Deoxycholic Acid, Disodium Salt
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Deoxycholic Acid, Magnesium (2:1) Salt
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Deoxycholic Acid, Monoammonium Salt
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Deoxycholic Acid, Monopotassium Salt
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Deoxycholic Acid, Monosodium Salt
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Deoxycholic Acid, Sodium Salt, 12beta-Isomer
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Deoxycholylglycine
A bile salt formed in the liver by conjugation of deoxycholate with glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and choleretic.

Deoxycholyltaurine
A bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholagogue and choleretic, also industrially as a fat emulsifier.

Deoxycoformycin
A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

Deoxycytidine Kinase
An enzyme that catalyzes reversibly the phosphorylation of deoxycytidine with the formation of a nucleoside diphosphate and deoxycytidine monophosphate. Cytosine arabinoside can also act as an acceptor. All natural nucleoside triphosphates, except deoxycytidine triphosphate, can act as donors. The enzyme is induced by some viruses, particularly the herpes simplex virus (HERPESVIRUS HOMINIS). EC 2.7.1.74.

Deoxycytidine Monophosphate Deaminase
An enzyme that catalyzes the hydrolytic deamination of deoxycytidylic acid to deoxyuridylic acid and ammonia. It plays an important role in the regulation of the pool of deoxynucleotides in higher organisms. The enzyme also acts on some 5-substituted deoxycytidylic acids. EC 3.5.4.12.

Deoxycytidine Phosphates
Cytosine nucleotides which contain deoxyribose as the sugar moiety.

Deoxycytidylate Aminohydrolase
An enzyme that catalyzes the hydrolytic deamination of deoxycytidylic acid to deoxyuridylic acid and ammonia. It plays an important role in the regulation of the pool of deoxynucleotides in higher organisms. The enzyme also acts on some 5-substituted deoxycytidylic acids. EC 3.5.4.12.

Deoxycytidylate Deaminase
An enzyme that catalyzes the hydrolytic deamination of deoxycytidylic acid to deoxyuridylic acid and ammonia. It plays an important role in the regulation of the pool of deoxynucleotides in higher organisms. The enzyme also acts on some 5-substituted deoxycytidylic acids. EC 3.5.4.12.

Deoxycytosine Nucleotides
Cytosine nucleotides which contain deoxyribose as the sugar moiety.

Deoxydemoxepam
An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.

Deoxydexamethasone
Topical anti-inflammatory glucocorticoid used in dermatoses, skin allergies, psoriasis, etc.

Deoxydinucleoside Phosphates
A group of compounds which consist of a nucleotide molecule to which an additional nucleoside is attached through the phosphate molecule(s). The nucleotide can contain any number of phosphates.

Deoxyephedrine
A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.

Deoxyepinephrine
Sympathomimetic, vasoconstrictor agent.

Deoxygenated Sickle Hemoglobin
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.

Deoxyglucose
2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.

Deoxyguanine Nucleotides
Guanine nucleotides which contain deoxyribose as the sugar moiety.

Deoxyguanosine
A nucleoside consisting of the base guanine and the sugar deoxyribose.

Deoxyguanosine Phosphates
Guanine nucleotides which contain deoxyribose as the sugar moiety.

Deoxyhemoglobin
The form of hemoglobin without oxygen, the predominant protein in red blood cells.

Deoxyhemoglobin S
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.

Deoxymannose
A methylpentose whose L- isomer is found naturally in many plant glycosides and some gram-negative bacterial lipopolysaccharides.

Deoxynucleoside Diphosphate Kinases
An enzyme that is found in mitochondria and in the soluble cytoplasm of cells. It catalyzes reversible reactions of a nucleoside triphosphate, e.g., ATP, with a nucleoside diphosphate, e.g., UDP, to form ADP and UTP. Many nucleoside diphosphates can act as acceptor, while many ribo- and deoxyribonucleoside triphosphates can act as donor. EC 2.7.4.6.

Deoxynucleotidyl Transferase
A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyzes the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukemias in man. EC 2.7.7.31.

Deoxynucleotidyl Transferase, Terminal
A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyzes the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukemias in man. EC 2.7.7.31.

Deoxynucleotidyltransferase
A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyzes the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukemias in man. EC 2.7.7.31.

Deoxyribodipyrimidine Photo Lyase
An enzyme that catalyzes the reactivation by light of UV-irradiated DNA. It breaks two carbon-carbon bonds in pyrimidine dimers in DNA. EC 4.1.99.3.

Deoxyribodipyrimidine Photo-Lyase
An enzyme that catalyzes the reactivation by light of UV-irradiated DNA. It breaks two carbon-carbon bonds in pyrimidine dimers in DNA. EC 4.1.99.3.

Deoxyribodipyrimidine Photolyase
An enzyme that catalyzes the reactivation by light of UV-irradiated DNA. It breaks two carbon-carbon bonds in pyrimidine dimers in DNA. EC 4.1.99.3.

Deoxyribonuclease BamHI
One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequence G/GATCC at the slash. BamHI is from Bacillus amyloliquefaciens N. Numerous isoschizomers have been identified. EC 3.1.21.-.

Deoxyribonuclease BstFI
One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequence A/AGCTT at the slash. HindIII is from Haemophilus influenzae R(d). Numerous isoschizomers have been identified. EC 3.1.21.-.

Deoxyribonuclease BstI
One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequence G/GATCC at the slash. BamHI is from Bacillus amyloliquefaciens N. Numerous isoschizomers have been identified. EC 3.1.21.-.

Deoxyribonuclease EcoRI
One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequence G/AATTC at the slash. EcoRI is from E coliRY13. Several isoschizomers have been identified. EC 3.1.21.-.

Deoxyribonuclease EcoVIII
One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequence A/AGCTT at the slash. HindIII is from Haemophilus influenzae R(d). Numerous isoschizomers have been identified. EC 3.1.21.-.

Deoxyribonuclease HindIII
One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequence A/AGCTT at the slash. HindIII is from Haemophilus influenzae R(d). Numerous isoschizomers have been identified. EC 3.1.21.-.

Deoxyribonuclease HpaII
One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequences C/CGG and GGC/C at the slash. HpaII is from Haemophilus parainfluenzae. Several isoschizomers have been identified. EC 3.1.21.-.

Deoxyribonuclease MspI
One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequences C/CGG and GGC/C at the slash. HpaII is from Haemophilus parainfluenzae. Several isoschizomers have been identified. EC 3.1.21.-.

Deoxyribonuclease S1
An enzyme that catalyzes endonucleolytic cleavage to 5-phosphomononucleotides and 5-phosphooligonucleotide end-products. It has a preference for single-stranded substrates but is active with either ribo- or deoxyribonucleic acids. (From Enzyme Nomenclature, 1992) EC 3.1.30.1.

Deoxyribonuclease SsoI
One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequence G/AATTC at the slash. EcoRI is from E coliRY13. Several isoschizomers have been identified. EC 3.1.21.-.

Deoxyribonucleic acid
DNA. A substance composed of a double chain of polynucleotides; both chains coiled around a central axis form a double helix. DNA is the basic genetic code or template for amino acid formation.

Deoxyribonucleic Acid
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Deoxyribonucleoproteins
Proteins conjugated with deoxyribonucleic acids (DNA) or specific DNA.

Deoxyribonucleosides
A purine or pyrimidine base bonded to DEOXYRIBOSE.

Deoxyribonucleosides, Adenine
Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.

Deoxyribonucleotides
A purine or pyrimidine base bonded to a DEOXYRIBOSE containing a bond to a phosphate group.

Deoxyribonucleotidyl Transferase, Terminal
A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyzes the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukemias in man. EC 2.7.7.31.

Deoxyribonucleotidyltransferase, Terminal
A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyzes the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukemias in man. EC 2.7.7.31.

Deoxyriboside, Bromouracil
A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.

Deoxyriboviruses, Icosahedral Cytoplasmic
A family of large icosahedral DNA viruses infecting insects and poikilothermic vertebrates. Genera include IRIDOVIRUS; RANAVIRUS; Chloriridovirus, and Lymphocystivirus.

Deoxyribozyme
Molecules of DNA that possess enzymatic activity.

Deoxyribozymes
Molecules of DNA that possess enzymatic activity.

Deoxythymidylate
5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety.

Deoxyuracil Nucleotides
Uracil nucleotides which contain deoxyribose as the sugar moiety.

Deoxyuridine Phosphates
Uracil nucleotides which contain deoxyribose as the sugar moiety.

Deoxyursocholic Acid
An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.



PREVIOUS AND NEXT TERMS
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Deoxyribonucleotides
A purine or pyrimidine base bonded to a DEOXYRIBOSE containing a bond to a phosphate group.

Deoxyribonuclease SsoI
One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequence G/AATTC at the slash. EcoRI is from E coliRY13. Several isoschizomers have been identified. EC 3.1.21.-.

Deoxyribonucleosides, Adenine
Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.

Deoxyribonucleosides
A purine or pyrimidine base bonded to DEOXYRIBOSE.

Deoxyribonucleic Acid
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Deoxyribonucleases

Deoxyribonuclease MspI
One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequences C/CGG and GGC/C at the slash. HpaII is from Haemophilus parainfluenzae. Several isoschizomers have been identified. EC 3.1.21.-.

Deoxyribonucleoproteins
Proteins conjugated with deoxyribonucleic acids (DNA) or specific DNA.

Deoxyribonuclease S1
An enzyme that catalyzes endonucleolytic cleavage to 5-phosphomononucleotides and 5-phosphooligonucleotide end-products. It has a preference for single-stranded substrates but is active with either ribo- or deoxyribonucleic acids. (From Enzyme Nomenclature, 1992) EC 3.1.30.1.

Department, Hospital Education
Hospital department responsible for administering educational and training activities pertaining to health for patients and staff.

Department, Hospital Anesthesia-Resuscitation
Hospital department responsible for the administration of functions and activities pertaining to the delivery of anesthetics.

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