DM2 Myotonic dystrophy type 2.
Partial atrophy of tissue or an organ as a result of imperfect cell nutrition.
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Dizziness before fainting. Some symptoms of dizziness such as wooziness, feeling about to black out, and tunnel vision may be pre-syncopal and are due to insufficient blood flow to the brain. These symptoms are typically worse when standing, improve with lying down and may be experienced by healthy individuals who rise quickly from a chair, often after a meal, and have a few seconds of disorientation.
A gene that inhibits the activity of osteoblasts, the cells that build bone. DKK1 acts by inhibiting Wnt signaling, which is essential for the growth and development of osteoblasts. DKK1 is overexpressed in the plasma cells in multiple myeloma. The DKK1 produced by the myeloma cells tips the balance between osteoblasts and osteoclasts in favor of bone resorption. This contributes to the maintenance of the lytic ("punched-out") lesions in bone characteristic of multiple myeloma. DKK1 stands for Dickkopf1.
Donor lymphocyte infusion.
Type 1 myotonic dystrophy.
DMD (dystonia musculorum deformans)
Also called torsion dystonia, this is a rare, generalized dystonia (a state of abnormal -- either excessive of inadequate -- muscle tone) that can be inherited, usually begins in childhood, and becomes progressively worse. It can leave individuals seriously disabled and confined to a wheelchair.
The production of multiple copies of a sequence of DNA. Repeated copying of a piece of DNA. DNA amplification plays a role in cancer cells. A tumor cell amplifies, or copies, DNA segments as a result of cell signals and sometimes environmental events. Amplification can occur in vivo (in the living individual) or in vitro (literally "in glass", or in a plastic vessel in the laboratory).
The process of putting fragments of DNA that have been sequenced into their correct chromosomal positions. The pieces of DNA are assembled to reconstitute the sequence of the chromosome from which they came.
The use of DNA manipulation procedures to produce multiple copies of a single gene or segment of DNA.
The application of DNA technology and the knowledge of DNA genetics to the practice of forensic medicine and to the power of legal medicine. Crime scene investigation has been markedly changed -- some would say revolutionized -- by the advent of DNA forensics. This has led to the invention of devices for DNA forensics. One is a plate of glass about the size of a hand is etched with very thin channels and reservoirs. A minute sample of DNA is moved between reservoir and channel through timed electric pulses. These thin channels then act like capillary tubes and can resolve the constituents of this minute sample of DNA. At the crime scene, the forensic technician can perform the PCR reactions for DNA fingerprinting and immediately resolve the samples on the glass plate. What normally would take more than a day, once the sample is taken to the laboratory, now takes only a few hours at the crime scene.
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