DIT Receptors
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  DIT Receptors

DIT Receptors

   Proteins, usually found in the nucleus, that specifically bind thyroid hormones and regulate DNA transcription. These proteins, termed c-erbA, are activated by hormones and cause differentiation of erythroid progenitor cells which irreversibly lose proliferative potential. Thus c-erbA proteins act as growth suppressors. The c-erbA proteins are encoded by at least two genes, c-erbA alpha and c-erbA beta. Each of these has two isoforms. Mutations in the ligand-binding domain of the beta form causes THYROID HORMONE RESISTANCE SYNDROME.


Plural: nuclei. The compartment of a cell that contains the chromosomes.

The gland in the throat that synthesizes thyroid hormones that affect metabolism.

Biological compounds that communicate information at a distance. Hormones require specific receptors to begin their biological action and use second messengers to initiate the cellular process that uses that information.

Making an RNA copy from a gene or other DNA sequence. Transcription is the first step in gene expression.

The process whereby an unspecialized early embryonic cell or stem cell acquires the features of a specialized cell, such as a heart, liver, or muscle cell.

Basic, functional units of heredity, each occupying a specific place on a chromosome.

compact segment of an immunoglobulin molecule, made up of about 110 amino acids around an S-S bond, and encoded by a unique segment of DNA, surrounded by nontranslated sequences.

A chemical substance formed in the body that is carried in the bloodstream to affect another part of the body; an example is thyroid hormone, produced by the thyroid gland in the neck, which affects growth, temperature regulation, metabolic rate, and other body functions.

A grouping of signs and symptoms, based on their frequent co-occurrence, that may suggest a common underlying pathogenesis, course, familial pattern, or treatment selection.



Disulfide, Thiamine Tetrahydrofurfuryl
Compound used for therapy of thiamine deficiency. It has also been suggested for several non-deficiency disorders but has not yet proven useful.

Disulfide, Tetramethylthiuram
A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme glutathione reductase. It has mutagenic activity and may induce chromosomal aberrations.

Disulfide, Tetraethylthiuram
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.

Disulfide, Glutathione
A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.

A pteridine that is used as a mild diuretic.

DIT Receptors

An organothiophosphate insecticide.

Disuse Atrophy
Disorders characterized by an abnormal reduction in muscle volume due to a decrease in the size or number of muscle fibers. Atrophy may result from diseases intrinsic to muscle tissue (e.g., MUSCULAR DYSTROPHY) or secondary to PERIPHERAL NERVOUS SYSTEM DISEASES that impair innervation to muscle tissue (e.g., MUSCULAR ATROPHY, SPINAL).

Disuse Atrophies
Disorders characterized by an abnormal reduction in muscle volume due to a decrease in the size or number of muscle fibers. Atrophy may result from diseases intrinsic to muscle tissue (e.g., MUSCULAR DYSTROPHY) or secondary to PERIPHERAL NERVOUS SYSTEM DISEASES that impair innervation to muscle tissue (e.g., MUSCULAR ATROPHY, SPINAL).

An organothiophosphate insecticide.

A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)

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