DIFFUSE
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  Diffuse



Diffuse

    Not definitely localized or limited; spread widely through a tissue or substance.

RELATED TERMS
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Tissue
Biological tissue is a group of cells that perform a similar function.The study of tissues is known as histology, or, in connection with disease, histopathology.The classical tools for studying the tissues are the wax block, the tissue stain, and the optical microscope, though developments in electron microscopy, immunofluorescence, and frozen sections have all added to the sum of knowledge in the last couple of decades.



SIMILAR TERMS
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Difference Limen
The smallest difference which can be discriminated between two stimuli or one which is barely above the threshold.

Difference Limens
The smallest difference which can be discriminated between two stimuli or one which is barely above the threshold.

Difference, Individual
Those psychological characteristics which differentiate individuals from one another.

Difference, Just-Noticeable
The smallest difference which can be discriminated between two stimuli or one which is barely above the threshold.

Difference, Sex
Those characteristics that distinguish one sex from the other. The primary sex characteristics are the ovaries and testes and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.

Differences, Individual
Those psychological characteristics which differentiate individuals from one another.

Differences, Just-Noticeable
The smallest difference which can be discriminated between two stimuli or one which is barely above the threshold.

Differences, Sex
Those characteristics that distinguish one sex from the other. The primary sex characteristics are the ovaries and testes and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.

Differentation Markers
Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.

Differential Diagnoses
Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures.

Differential diagnosis
The determination of which two or more diseases with similar symptoms is the one from which a patient is suffering, based on an analysis of the clinical data.

Differential Diagnosis
Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures.

Differential Display, mRNA
The determination of the pattern of genes expressed i.e., transcribed, under specific circumstances or in a specific cell.

Differential Displays, mRNA
The determination of the pattern of genes expressed i.e., transcribed, under specific circumstances or in a specific cell.

Differential Leukocyte Count
A count of the number of white blood cells per unit volume in venous blood. A differential leukocyte count measures the relative numbers of the different types of white cells.

Differential Leukocyte Counts
A count of the number of white blood cells per unit volume in venous blood. A differential leukocyte count measures the relative numbers of the different types of white cells.

Differential Mortalities
All deaths reported in a given population.

Differential Mortality
All deaths reported in a given population.

Differential Scanning Calorimetry
Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.

Differential Thermal Analyses
Technique by which phase transitions of chemical reactions can be followed by observation of the heat absorbed or liberated.

Differential Thermal Analysis
Technique by which phase transitions of chemical reactions can be followed by observation of the heat absorbed or liberated.

Differential Thermal Analysis, Calorimetric
Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.

Differential Threshold
The smallest difference which can be discriminated between two stimuli or one which is barely above the threshold.

Differential Thresholds
The smallest difference which can be discriminated between two stimuli or one which is barely above the threshold.

Differential white cell count
The proportions of the different types of white cells in the blood, usually split into the different types of granulocytes, lymphocytes, monocytes, eosinophils, and basophils. The differential white cell count was originally done by visual inspection of the blood and is now often machine-generated. Normal values are: 24-62% neutrophils, 19-53% lymphocytes, 2-12% monocytes, 0-7% eosinophils, and 0-2% basophils.

Differentiate
The process cells undergo as they mature into normal cells. Differentiated cells have distinctive characteristics, perform specific functions, and are less likely to divide. See dedifferentiate, undifferentiated.

Differentiated
Having developed into a specialized cell or tissue type .

Differentiated cancer
A cancer in which the cells are mature and look like cells in the tissue from it arose. Differentiated cancers tend to be decidedly less aggressive than undifferentiated cancers composed of immature cells.

Differentiated Gene
Genes that code for proteins required for the enzymatic and structural functions of cells. They include developmental and differentiated genes.

Differentiated Genes
Genes that code for proteins required for the enzymatic and structural functions of cells. They include developmental and differentiated genes.

Differentiation
The process whereby an unspecialized early embryonic cell or stem cell acquires the features of a specialized cell, such as a heart, liver, or muscle cell.

Differentiation antigen
A cell surface antigenic determinant found only on cells of a certain lineage and at a particular developmental stage; used as an immunologic marker.

Differentiation Antigens
Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.

Differentiation Antigens, B Cell
Membrane antigens associated with maturation stages of B-lymphocytes, often expressed in tumors of B-cell origin.

Differentiation Antigens, B Lymphocyte
Membrane antigens associated with maturation stages of B-lymphocytes, often expressed in tumors of B-cell origin.

Differentiation Antigens, B-Cell
Membrane antigens associated with maturation stages of B-lymphocytes, often expressed in tumors of B-cell origin.

Differentiation Antigens, B-Lymphocyte
Membrane antigens associated with maturation stages of B-lymphocytes, often expressed in tumors of B-cell origin.

Differentiation Antigens, Hairy Cell Leukemia
Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.

Differentiation Antigens, Leukocyte, Human
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similiar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.

Differentiation Antigens, Myelomonocytic
Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. Analysis of their reactivity in normal and malignant myelomonocytic cells is useful in identifying and classifying human leukemias and lymphomas.

Differentiation Antigens, T Cell
Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function.

Differentiation Antigens, T Lymphocyte
Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function.

Differentiation Antigens, T-Cell
Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function.

Differentiation Antigens, T-Lymphocyte
Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function.

Differentiation Antigens, VLA
Members of the integrin family appearing late after T-cell activation. They are a family of proteins initially identified at the surface of stimulated T-cells, but now identified on a variety of cell types. At least six VLA antigens have been identified as heterodimeric adhesion receptors consisting of a single common beta-subunit and different alpha-subunits.

Differentiation Disorder, Sex
Disorders in the differentiation process of gonadal tissues and organs during embryogenesis.

Differentiation Disorders, Sex
Disorders in the differentiation process of gonadal tissues and organs during embryogenesis.

Differentiation Factor 2, B Cell
Factor that stimulates the growth and differentiation of human B-cells and is also a growth factor for hybridomas and plasmacytomas. It is produced by many different cells including T-cells, monocytes, and fibroblasts.

Differentiation Factor, B Cell
Factor that stimulates the growth and differentiation of human B-cells and is also a growth factor for hybridomas and plasmacytomas. It is produced by many different cells including T-cells, monocytes, and fibroblasts.

Differentiation Factor, B-Cell
Factor that stimulates the growth and differentiation of human B-cells and is also a growth factor for hybridomas and plasmacytomas. It is produced by many different cells including T-cells, monocytes, and fibroblasts.

Differentiation Factor, Eosinophil
Factor promoting eosinophil differentiation and activation in hematopoiesis. It also triggers activated B-cells for a terminal differentiation into Ig-secreting cells.

Differentiation Factor, neu
A peptide factor originally identified by its ability to stimulate the phosphorylation the erbB-2 receptor (RECEPTOR, ERBB-2). It is a ligand for the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Variant forms of NEUREGULIN-1 occur through alternative splicing of its mRNA.

Differentiation Factor-2, B-Cell
Factor that stimulates the growth and differentiation of human B-cells and is also a growth factor for hybridomas and plasmacytomas. It is produced by many different cells including T-cells, monocytes, and fibroblasts.

Differentiation Markers
Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.

Differentiation Reversal Factor
A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.

Differentiation therapy
An approach to the treatment of advanced or aggressive malignancies in which the malignant cells are treated so that they can resume the process of maturation and differentiation into mature cells.

Differentiation, Cell
Progressive restriction of the developmental potential and increasing specialization of function which takes place during the development of the embryo and leads to the formation of specialized cells, tissues, and organs.

Differentiation, Sex
Differentiation of male and female tissues and organs during embryogenesis, but after sex determination (SEX DETERMINATION (GENETICS)).

Differentiation-Inducing Protein, Myeloid
Factor that stimulates the growth and differentiation of human B-cells and is also a growth factor for hybridomas and plasmacytomas. It is produced by many different cells including T-cells, monocytes, and fibroblasts.

Differentiations, Cell
Progressive restriction of the developmental potential and increasing specialization of function which takes place during the development of the embryo and leads to the formation of specialized cells, tissues, and organs.

Differin
Differin is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): adapalene.

Diffraction
The scattering of rays of light by collision with particles of matter as they pass through a medium such as air or water, or pass by a edge or narrow aperture. Plays a role when the pupil is small.

Diffraction, X-Ray
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Diffraction, Xray
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Diffractions, X-Ray
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Diffractions, Xray
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Diffuse Axonal Injuries
A relatively common sequela of blunt head injury, characterized by a global disruption of axons throughout the brain. Associated clinical features may include NEUROBEHAVIORAL MANIFESTATIONS; PERSISTENT VEGETATIVE STATE; DEMENTIA; and other disorders.

Diffuse Axonal Injury
A relatively common sequela of blunt head injury, characterized by a global disruption of axons throughout the brain. Associated clinical features may include NEUROBEHAVIORAL MANIFESTATIONS; PERSISTENT VEGETATIVE STATE; DEMENTIA; and other disorders.

Diffuse Brain Injuries
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.

Diffuse Brain Injury
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.

Diffuse Cutaneous Leishmaniases
A form of LEISHMANIASIS, CUTANEOUS caused by Leishmania aethiopica in Ethiopia and Kenya, L. pifanoi in Venezuela, L. braziliensis in South America, and L. mexicana in Central America. This disease is characterized by massive dissemination of skin lesions without visceral involvement.

Diffuse Cutaneous Leishmaniasis
A form of LEISHMANIASIS, CUTANEOUS caused by Leishmania aethiopica in Ethiopia and Kenya, L. pifanoi in Venezuela, L. braziliensis in South America, and L. mexicana in Central America. This disease is characterized by massive dissemination of skin lesions without visceral involvement.

Diffuse Cutaneous Mastocytoses
The most common form of mastocytosis. It occurs primarily in children and is typically characterized by multiple persistent small, reddish-brown, hyperpigmented, pruritic macules and papules. They are located most commonly on the trunk, but seen also on the extremities, head, and neck. (Dorland, 27th ed)

Diffuse Cutaneous Mastocytosis
The most common form of mastocytosis. It occurs primarily in children and is typically characterized by multiple persistent small, reddish-brown, hyperpigmented, pruritic macules and papules. They are located most commonly on the trunk, but seen also on the extremities, head, and neck. (Dorland, 27th ed)

Diffuse degeneration of gray matter with cirrhosis
A progressive disease of the nervous system characterized by spasticity (tightness), myoclonus and dementia and by liver problems with jaundice and cirrhosis.

Diffuse Esophageal Spasm
A motor disorder of the esophagus characterized by chest pain and dysphagia. Pathogenesis is unclear. Strong, nonpropulsive contractions of the esophagus evoked by deglutition occur, especially in the elderly.

Diffuse Esophageal Spasms
A motor disorder of the esophagus characterized by chest pain and dysphagia. Pathogenesis is unclear. Strong, nonpropulsive contractions of the esophagus evoked by deglutition occur, especially in the elderly.

Diffuse Globoid Body Sclerosis
An autosomal recessive inherited sphingolipidosis caused by a deficiency of GALACTOSYLCERAMIDASE leading to an accumulation of PSYCHOSINE in LYSOSOMES of the BRAIN; PERIPHERAL NERVES; LIVER; KIDNEY; and LEUKOCYTES. In the nervous sytem there is prominent central and peripheral demyelination. The infantile form presents at age 4-6 months with psychomotor retardation, MUSCLE SPASTICITY, and tonic spasms induced by minor stimuli. Death occurs within two years. Later onset forms of this disease are characterized by a less fulminant course. (From Menkes, Textbook of Child Neurology, 5th ed, pp195-7)

Diffuse Histiocytic Lymphoma
Malignant lymphoma composed of large cells which may be both cleaved and noncleaved. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.

Diffuse Histiocytic Lymphomas
Malignant lymphoma composed of large cells which may be both cleaved and noncleaved. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.

Diffuse idiopathic skeletal hyperostosis
Abbreviated as DISH. A form of degenerative arthritis characteristically associated with flowing calcification along the sides of the vertebrae of the spine and commonly associated with inflammation (tendinitis) and calcification of the tendons at their attachments points to bone. Because areas of the spine and tendons can become inflamed, antiinflammatory medications (NSAIDs) such ibuprofen can be helpful in both relieving pain and inflammation.

Diffuse Idiopathic Skeletal Hyperostosis
A disease of elderly men characterized by large osteophytes that bridge vertebrae and ossification of ligaments and tendon insertions.

Diffuse Immunoblastic Lymphosarcoma
Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.

Diffuse Immunoblastic Lymphosarcomas
Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.

Diffuse Large Cell Lymphoma
Malignant lymphoma composed of large cells which may be both cleaved and noncleaved. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.

Diffuse Large Follicular Center Cell Lymphoma
Malignant lymphoma composed of large cells which may be both cleaved and noncleaved. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.

Diffuse Large Follicular Center-Cell Lymphoma
Malignant lymphoma composed of large cells which may be both cleaved and noncleaved. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.

Diffuse Large-Cell Lymphoma
Malignant lymphoma composed of large cells which may be both cleaved and noncleaved. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.

Diffuse Large-Cell Lymphomas
Malignant lymphoma composed of large cells which may be both cleaved and noncleaved. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.

Diffuse Lewy Body Disease
A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)

Diffuse Lymphocytic Lymphoma, Poorly Differentiated
A rare form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the cyclin D1 gene (GENES, BCL-1).

Diffuse Lymphocytic Lymphoma, Poorly-Differentiated
A rare form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the cyclin D1 gene (GENES, BCL-1).

Diffuse Lymphoma
Malignant lymphoma in which neoplastic cells diffusely infiltrate the entire lymph node without any definite organized pattern. Patients whose lymphomas present a diffuse pattern generally have a more unfavorable survival outlook than those presenting with a follicular or nodular pattern.

Diffuse Lymphomas
Malignant lymphoma in which neoplastic cells diffusely infiltrate the entire lymph node without any definite organized pattern. Patients whose lymphomas present a diffuse pattern generally have a more unfavorable survival outlook than those presenting with a follicular or nodular pattern.

Diffuse mastocytosis
A form of mastocytosis in which the entire skin is thickened and leathery with generalized reddening and intense pruritus (itching) due to widespread infiltration of the skin with mast cells.

Diffuse Mixed Cell Lymphoma
A heterogeneous group of intermediate-grade lymphomas of mixed cellular composition. Although they have not been extensively studied, it appears that they are predominantly B-cell diseases.

Diffuse Mixed Small and Large Cell Lymphoma
A heterogeneous group of intermediate-grade lymphomas of mixed cellular composition. Although they have not been extensively studied, it appears that they are predominantly B-cell diseases.

Diffuse Mixed-Cell Lymphoma
A heterogeneous group of intermediate-grade lymphomas of mixed cellular composition. Although they have not been extensively studied, it appears that they are predominantly B-cell diseases.

Diffuse Mixed-Cell Lymphomas
A heterogeneous group of intermediate-grade lymphomas of mixed cellular composition. Although they have not been extensively studied, it appears that they are predominantly B-cell diseases.

Diffuse Myofascial Pain Syndrome
A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)

Diffuse Small Cleaved Cell Lymphoma
An intermediate-grade malignant lymphoma in which the neoplastic cells (B-lymphocytes) exhibit variability in size, configuration, and degree of differentiation. The cells are irregular in shape and have distinct nuclei.

Diffuse Small Cleaved-Cell Lymphoma
An intermediate-grade malignant lymphoma in which the neoplastic cells (B-lymphocytes) exhibit variability in size, configuration, and degree of differentiation. The cells are irregular in shape and have distinct nuclei.

Diffuse toxic goiter
Graves disease, the most common cause of hyperthyroidism (overactivity of the thyroid gland), with generalized diffuse overactivity ("toxicity") of the entire thyroid gland which becomes enlarged into a goiter.

Diffuse Undifferentiated Lymphoma
A high-grade malignant lymphoma that includes both Burkitt tumor (BURKITT LYMPHOMA) and other lymphomas previously designated undifferentiated non-Burkitt type. Nuclei in Burkitt tumor are round to ovoid and uniform in size. The non-Burkitt type exhibits greater nuclear variation and less evidence of cellular maturation with a correspondingly lesser degree of differentiation.

Diffuse Undifferentiated Lymphomas
A high-grade malignant lymphoma that includes both Burkitt tumor (BURKITT LYMPHOMA) and other lymphomas previously designated undifferentiated non-Burkitt type. Nuclei in Burkitt tumor are round to ovoid and uniform in size. The non-Burkitt type exhibits greater nuclear variation and less evidence of cellular maturation with a correspondingly lesser degree of differentiation.

Diffuse Well Differentiated Lymphocytic Lymphoma
A low-grade malignant lymphoma that may, in some cases, be considered histologically identical to chronic lymphocytic leukemia (CLL; LEUKEMIA, LYMPHOCYTIC, CHRONIC). It is diffuse in pattern, representing the neoplastic proliferation of well-differentiated B-lymphocytes. In patients with immunoglobulin gammopathies, the lymphocytes may exhibit plasmacytoid characteristics.

Diffuse Well-Differentiated Lymphocytic Lymphoma
A low-grade malignant lymphoma that may, in some cases, be considered histologically identical to chronic lymphocytic leukemia (CLL; LEUKEMIA, LYMPHOCYTIC, CHRONIC). It is diffuse in pattern, representing the neoplastic proliferation of well-differentiated B-lymphocytes. In patients with immunoglobulin gammopathies, the lymphocytes may exhibit plasmacytoid characteristics.

Diffusing Capacity, Pulmonary
The amount of a gas, usually oxygen or carbon dioxide, taken up by pulmonary capillary blood per minute per unit of average oxygen pressure gradient between alveolar gas and pulmonary capillary blood.

Diffusion
The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space; a major mechanism of BIOLOGICAL TRANSPORT.

Diffusion Chamber, Culture
Devices used in a technique by which cells or tissues are grown in vitro or, by implantation, in vivo within chambers permeable to diffusion of solutes across the chamber walls. The chambers are used for studies of drug effects, osmotic responses, cytogenic and immunologic phenomena, metabolism, etc., and include tissue cages.

Diffusion Chambers, Culture
Devices used in a technique by which cells or tissues are grown in vitro or, by implantation, in vivo within chambers permeable to diffusion of solutes across the chamber walls. The chambers are used for studies of drug effects, osmotic responses, cytogenic and immunologic phenomena, metabolism, etc., and include tissue cages.

Diffusion of Innovation
The broad dissemination of new ideas, procedures, techniques, materials, and devices and the degree to which these are accepted and used.

Diffusion Test, Gel
Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.

Diffusion Tests, Gel
Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.

Diffusion, Innovation
The broad dissemination of new ideas, procedures, techniques, materials, and devices and the degree to which these are accepted and used.

Diffusions
The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space; a major mechanism of BIOLOGICAL TRANSPORT.



PREVIOUS AND NEXT TERMS
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Direction selectivity
A difference in the response of a cell to a pattern of light moving through it receptive field according to the direction of movement. Cells respond well when a stimulus moves in one direction and not in the opposite direction.

Discounting the illuminant
Illumination of the visual world tens to be non-uniform, and fluctuates. in order for the visual system to create a consistent perception of color and lightness it must somehow discount fluctuation and gradient in the lighting source.

Disparity gradient
The ratio of the difference between two feature's disparities and their cyclopean separation. Steeply slanted surfaces have large disparity gradients. Human binocular fusion will only tolerate a disparity gradient of about 1.

Dorsal pathway
One of two theorized systems of visual information processing. Information thought to progress toward the parietal cortex V1-> V2 -> MT -> MST -> STP. Functions in comprehension of spatial arrangement.

Derma
Skin.

Diffuse

Diphtheritic membrane
A thin coating on the surface of an epithelial lined organ (e.g. intestine) that is composed of necrotic cellular debris, inflammatory cells and fibrin.

Dysgenesis
Defective embryonic development.

Dystopia
Displacement.

Da Costa's syndrome
Neurocirculatory asthenia; "soldier's heart"; a functional disorder of the circulatory system that is usually a part of an anxiety state or secondary to hyperventilation.

Decompensation
The deterioration of existing defenses, leading to an exacerbation of pathological behavior.

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