Corneal dystrophy, Fuchs endothelial
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  Corneal dystrophy, Fuchs endothelial



Corneal dystrophy, Fuchs endothelial

   A common adult-onset form of corneal dystrophy with autosomal dominant inheritance. The disorder is caused by mutation in the COL8A2 gene.

RELATED TERMS
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Corneal
Pertaining to the cornea, the clear front window of the eye that transmits and focuses light into the eye.

Dystrophy
Partial atrophy of tissue or an organ as a result of imperfect cell nutrition.

Autosomal
"Pertaining to a chromosome that is not a sex chromosome; relating to any one of the chromosomes save the sex chromosomes. People normally have 22 pairs of autosomes (44 autosomes) in each cell together with two sex chromosomes (X and Y in the male and XX in the female). "

Dominant
A genetic trait is considered dominant if it is expressed in a person who has only one copy of that gene. (In genetic terms, a dominant trait is one that is phenotypically expressed in heterozygotes). A dominant trait is opposed to a recessive trait which is expressed only when two copies of the gene are present. (In genetic terms, a recessive trait is one that is phenotypically expressed only in homozygotes).

Mutation
A change in DNA that alters a gene and thus the gene's product, leading in some cases to deformity or disease. Mutations can occur spontaneously during cell division or can be triggered by environmental stresses, such as sunlight, radiation, and chemicals.

Gene
1. A unit of DNA that carries information for the biosynthesis of a specific product in the cell. 2. Ultimate unit by which inheritable characteristics are transmitted to succeeding generations in all living organisms. Genes are contained by, and arranged along the length of, the chromosome. The gene is composed of deoxyribonucleic acid (DNA). Each chromosome of each species has a definite number and arrangement of genes, which govern both the structure and metabolic functions of the cells and thus of the entire organism.



SIMILAR TERMS
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Corn
A hardened area of skin on the foot caused by persistent friction or pressure.

Cornea
The front part of the eye that acts as a window for the entrance of light rays. It is attached to the other outer coat of the eye, the sclera; the white part of the eye. The cornea provides a significant amount of focusing power for the eye (the rest is provided by the lens). Because it has many nerve fibers, an injury or foreign body causes significant pain and discomfort.

Corneal
Pertaining to the cornea, the clear front window of the eye that transmits and focuses light into the eye.

Corneal abrasion
A scratch or scrape on the cornea, the clear front window of the eye that transmits and focuses light into the eye.

Corneal dystrophy
A condition in which one or more parts of the cornea lose their normal clarity due to a buildup of cloudy material. There are over 20 corneal dystrophies that affect all parts of the cornea.

Corneal dystrophy, Cogan
A disorder in which the cornea (the normally clear front window of the eye) shows grayish fingerprint lines, geographic map-like lines, and dots (or microcysts) on examination with a slit-lamp that focuses a high intensity light beam as a slit while the examiner looks at the front of the eye through a magnifying scope. The disorder is usually silent and without symptoms. However, about one patient in ten has recurrent erosion of the cornea that usually begins after the age 30.

Corneal dystrophy, epithelial basement
A disorder in which the cornea (the normally clear front window of the eye) shows grayish fingerprint lines, geographic map-like lines, and dots (or microcysts) on examination with a slit-lamp that focuses a high intensity light beam as a slit while the examiner looks at the front of the eye through a magnifying scope. The disorder is usually silent and without symptoms. However, about one patient in ten has recurrent erosion of the cornea that usually begins after the age 30.

Corneal dystrophy, map-dot-fingerprint type
A disorder in which the cornea (the normally clear front window of the eye) shows geographic map-like lines, dots (or microcysts), and grayish fingerprint lines on examination with a slit-lamp, a device that focuses a high intensity light beam as a slit while the examiner looks at the front of the eye through a magnifying scope.

Corneal dystrophy, microcystic
A disorder in which the cornea (the normally clear front window of the eye) shows dots (or microcysts), geographic map-like lines, and grayish fingerprint lines on examination with a slit-lamp, a device that focuses a high intensity light beam as a slit while the examiner looks at the front of the eye through a magnifying scope. The disorder is usually silent and without symptoms. However, about one patient in ten has recurrent erosion of the cornea that usually begins after the age 30.

Corneal ring, intrastromal
A plastic ring designed to be implanted in the cornea, the transparent structure in the front of the eye.

Corns
Small calloused areas of skin caused by local pressure irritating tissue over a bony prominence. Corns most commonly occur over a toe where they form what is referred to as a hard corn. Between the toes, pressure can form a soft corn of macerated skin which often yellows.

Cornwall Regional Hospital
The Cornwall Regional Hospital is a hospital in St James, Jamaica.



PREVIOUS AND NEXT TERMS
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Corneal
Pertaining to the cornea, the clear front window of the eye that transmits and focuses light into the eye.

Corneal abrasion
A scratch or scrape on the cornea, the clear front window of the eye that transmits and focuses light into the eye.

Corneal dystrophy
A condition in which one or more parts of the cornea lose their normal clarity due to a buildup of cloudy material. There are over 20 corneal dystrophies that affect all parts of the cornea.

Corneal dystrophy, Cogan
A disorder in which the cornea (the normally clear front window of the eye) shows grayish fingerprint lines, geographic map-like lines, and dots (or microcysts) on examination with a slit-lamp that focuses a high intensity light beam as a slit while the examiner looks at the front of the eye through a magnifying scope. The disorder is usually silent and without symptoms. However, about one patient in ten has recurrent erosion of the cornea that usually begins after the age 30.

Corneal dystrophy, epithelial basement
A disorder in which the cornea (the normally clear front window of the eye) shows grayish fingerprint lines, geographic map-like lines, and dots (or microcysts) on examination with a slit-lamp that focuses a high intensity light beam as a slit while the examiner looks at the front of the eye through a magnifying scope. The disorder is usually silent and without symptoms. However, about one patient in ten has recurrent erosion of the cornea that usually begins after the age 30.

Corneal dystrophy, Fuchs endothelial

Corneal dystrophy, map-dot-fingerprint type
A disorder in which the cornea (the normally clear front window of the eye) shows geographic map-like lines, dots (or microcysts), and grayish fingerprint lines on examination with a slit-lamp, a device that focuses a high intensity light beam as a slit while the examiner looks at the front of the eye through a magnifying scope.

Corneal dystrophy, microcystic
A disorder in which the cornea (the normally clear front window of the eye) shows dots (or microcysts), geographic map-like lines, and grayish fingerprint lines on examination with a slit-lamp, a device that focuses a high intensity light beam as a slit while the examiner looks at the front of the eye through a magnifying scope. The disorder is usually silent and without symptoms. However, about one patient in ten has recurrent erosion of the cornea that usually begins after the age 30.

Corneal ring, intrastromal
A plastic ring designed to be implanted in the cornea, the transparent structure in the front of the eye.

Corns
Small calloused areas of skin caused by local pressure irritating tissue over a bony prominence. Corns most commonly occur over a toe where they form what is referred to as a hard corn. Between the toes, pressure can form a soft corn of macerated skin which often yellows.

Coronal
A coronal plane through the body is a vertical plane from head to foot and parallel to the shoulders.

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