CYP2E1
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  CYP2E1



CYP2E1

   A polymorphic enzyme that activates carcinogenic N-nitrosamines, benzene, urethane, and other low molecular weight compounds. It is inducible by ethanol and metabilizes alcohol. Experimentally, it is used to study the effects of ethanol usage and withdrawal via enzyme markers such as N-nitrosodimethylamine demethylase. (Pharmacogenetics 1995;5 Spec No:S141-4) EC 1.5.99.-.

RELATED TERMS
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Enzyme
A cellular protein whose shape allows it to hold together several other molecules in close proximity to each other. In this way, enzymes are able to induce chemical reactions in other substances with little expenditure of energy and without being changed themselves. Basically, an enzyme acts as a catalyst.

Carcinogenic
Of a substance which causes cancer.

Benzene
A sweet smelling, highly toxic hydrocarbon. Long-term exposure to benzene is known to cause anemia and leukemia. The anemia associated with benzene exposure is termed aplastic anemia. The types of leukemia associated with benzene exposure are adult acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL). It is thought that benzene induces DNA damage in hematopoietic stem cells that give rise to leukemic clones of cells.

Molecular
Refers to the basic building blocks of the genetic material, such as DNA, genes and the other chemicals involved with the functioning of genes.

Ethanol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.

Alcohol
An organic chemical in which one or more hydroxyl (OH) groups are attached to carbon (C) atoms in place of hydrogen (H) atoms. Common alcohols include ethyl alcohol or ethanol (found in alcoholic beverages), methyl alcohol or methanol (can cause blindness) and propyl alcohol or propanol (used as a solvent and antiseptic). Rubbing alcohol is a mixture of acetone, methyl isobutyl ketone, and ethyl alcohol. In everyday talk, alcohol usually refers to ethanol as, for example, in wine, beer, and liquor. It can cause changes in behavior and be addictive.

Withdrawal
The act or process of giving up the use of a drug to which one has become addicted or dependent.



SIMILAR TERMS
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CYP27B1
An enzyme that catalyzes the formation of 1,25-dihydroxycholecalciferol from 25-hydroxycholecalciferol. The reaction requires oxygen, magnesium, and NAD(P)H. EC 1.14.13.13.

CYP2B1
A major cytochrome P-450 enzyme which is inducible by phenobarbital in both the liver and small intestine. It is active in the metabolism of compounds like pentoxyresorufin, testosterone, and androstenedione. CYP2B1 also mediates the activation of cyclophosphamide and ifosfamide to mutagens. EC 1.-.

CYP2B1, Cytochrome P-450
A major cytochrome P-450 enzyme which is inducible by phenobarbital in both the liver and small intestine. It is active in the metabolism of compounds like pentoxyresorufin, testosterone, and androstenedione. CYP2B1 also mediates the activation of cyclophosphamide and ifosfamide to mutagens. EC 1.-.

CYP2D6
A polymorphic enzyme that catalyzes the hydroxylation of debrisoquine. It also metabolizes several antidepressants and neuroleptics. This enzyme is deficient in up to 10 percent of the population. (Psychopharmacol Bull 1995; 31(2): 327-331) EC 1.14.99.-.

CYP2D6, Cytochrome P-450
A polymorphic enzyme that catalyzes the hydroxylation of debrisoquine. It also metabolizes several antidepressants and neuroleptics. This enzyme is deficient in up to 10 percent of the population. (Psychopharmacol Bull 1995; 31(2): 327-331) EC 1.14.99.-.

CYP2E1, Cytochrome P-450
A polymorphic enzyme that activates carcinogenic N-nitrosamines, benzene, urethane, and other low molecular weight compounds. It is inducible by ethanol and metabilizes alcohol. Experimentally, it is used to study the effects of ethanol usage and withdrawal via enzyme markers such as N-nitrosodimethylamine demethylase. (Pharmacogenetics 1995;5 Spec No:S141-4) EC 1.5.99.-.



PREVIOUS AND NEXT TERMS
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Cyperaceae
The sedge plant family of the order Cyperales, subclass Commelinidae, class Liliopsida (monocotyledons)

CYP7
An enzyme that catalyzes the hydroxylation of cholesterol to cholest-5-en-3 beta,7 alpha-diol. EC 1.14.13.17.

CYP7A
An enzyme that catalyzes the hydroxylation of cholesterol to cholest-5-en-3 beta,7 alpha-diol. EC 1.14.13.17.

CYP7, Cytochrome P-450
An enzyme that catalyzes the hydroxylation of cholesterol to cholest-5-en-3 beta,7 alpha-diol. EC 1.14.13.17.

CYP2E1, Cytochrome P-450
A polymorphic enzyme that activates carcinogenic N-nitrosamines, benzene, urethane, and other low molecular weight compounds. It is inducible by ethanol and metabilizes alcohol. Experimentally, it is used to study the effects of ethanol usage and withdrawal via enzyme markers such as N-nitrosodimethylamine demethylase. (Pharmacogenetics 1995;5 Spec No:S141-4) EC 1.5.99.-.

CYP2E1

CYP2D6
A polymorphic enzyme that catalyzes the hydroxylation of debrisoquine. It also metabolizes several antidepressants and neuroleptics. This enzyme is deficient in up to 10 percent of the population. (Psychopharmacol Bull 1995; 31(2): 327-331) EC 1.14.99.-.

CYP2D6, Cytochrome P-450
A polymorphic enzyme that catalyzes the hydroxylation of debrisoquine. It also metabolizes several antidepressants and neuroleptics. This enzyme is deficient in up to 10 percent of the population. (Psychopharmacol Bull 1995; 31(2): 327-331) EC 1.14.99.-.

CYP2B1, Cytochrome P-450
A major cytochrome P-450 enzyme which is inducible by phenobarbital in both the liver and small intestine. It is active in the metabolism of compounds like pentoxyresorufin, testosterone, and androstenedione. CYP2B1 also mediates the activation of cyclophosphamide and ifosfamide to mutagens. EC 1.-.

Cyprinodons
Small oviparous fishes in the family Cyprinodontidae, usually striped or barred black. They are much used in mosquito control.

Cyprinodon
Small oviparous fishes in the family Cyprinodontidae, usually striped or barred black. They are much used in mosquito control.

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