Big toe sign
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  Big toe sign

Big toe sign

   An important neurologic examination based upon what the big toe (and other toes) do when the sole of the foot is stimulated. If the big toe goes up, that may mean trouble.


The distal portion of the leg, upon which an individual stands and walks. It consists, in man, of the tarsus, metatarsus, and phalanges and the tissues encompassing them.

The sum of the values of all observations or data points divided by the number of observations, an arithmetical average.


Big bone disease
See: Kashin-Beck disease.

Big Country Health Centre
The Big Country Health Centre is a hospital in Lloydminster, Alberta, Canada.


Bid (on prescription)
"Seen on a prescription, bid means twice (two times) a day. It is an abbreviation for ""bis in die"" which in Latin means twice a day. The abbreviation bid is sometimes written without a period either in lower-case letters as ""bid"" or in capital letters as ""BID"" or with periods as ""b.i.d."" However it is written, it is one of a number of hallowed abbreviations of Latin terms that have been traditionally used in prescriptions to specify the frequency with which medicines should be taken. "

Bietti crystalline dystrophy
A genetic eye disease that leads to progressive night blindness and visual field constriction and is characterized by the formation of crystals in the cornea (the clear covering of the eye), yellow shiny deposits on the retina, and progressive atrophy of the retina and choroid (the back layers of the eye). Average age of onset is 29. Lipid inclusions are present not only in the cornea but also in blood lymphocytes, suggesting a systemic disorder of lipid metabolism. There is no known treatment. The disease is an autosomal recessive trait (the gene is on chromosome 4q35-qter) and is named for G. B. Bietti, an Italian ophthalmologist, who described it in 1937. Also called Bietti crystalline corneoretinal dystrophy.

Cleft (split) in two. See, for example, bifid uvula.

Bifid uvula
The uvula, the little V-shaped fleshy mass hanging from the back of the soft palate, is cleft or split. Cleft uvula is a common minor anomaly occurring in about 1% of whites and 10% of Native Americans. Persons with a cleft uvula should not have their adenoids removed because, without the adenoids, they cannot achieve proper closure between the soft palate and pharynx while speaking and develop hypernasal speech.

Big bone disease
See: Kashin-Beck disease.

Big toe sign

Body integrity identity disorder.

Bilateral pneumonia
See: Pneumonia, bilateral.

Bile acid
An acid made by the liver that works with bile to break down fats. On a more technical level, bile acids are steroid carboxylic acids derived from cholesterol. The primary bile acids are cholic and chenodeoxycholic acids. They are conjugated with glycine or taurine before they are secreted into the bile.

Bile acid resin
Bile acid resins are substances that bind in the intestines with bile acids that contain cholesterol and are then eliminated in the stool. The major effect of bile acid resins is to lower LDL-cholesterol by about 10 to 20 percent. Small doses of resins can produce useful reductions in LDL-cholesterol. Bile acid resins are sometimes prescribed with a statin for patients with heart disease to increase cholesterol reduction. When these two drugs are combined, their effects are added together to lower LDL-cholesterol by over 40 percent.

Bile duct cancer
An uncommon type of cancer that arises from the bile duct, the tube that connects the liver and the gallbladder to the small intestine.

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